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Downregulation of endothelial adhesion molecules by dimethylfumarate, but not monomethylfumarate, and impairment of dynamic lymphocyte-endothelial cell interactions.
Participants will also undergo blood draws and complete several surveys during their monthly study visits.
However, it is not approved by the FDA for the treatment of OSA and is thus considered an investigational drug in this study.
Consenting participants will receive a baseline overnight sleep study to assess their current sleep apnea severity.
Scannevin RH, Chollate S, Jung MY, Shackett M, Patel H, Bista P, Zeng W, Ryan S, Yamamoto M, Lukashev M, Rhodes KJ.
As OSA may also be caused or worsened by inflammation, this clinical trial aims to study the effects of a specific MS medication known as dimethyl fumarate (brand name - Tecfidera®) to see if it may also be useful to treat OSA.
Untreated OSA increases the risk of many health consequences, including high blood pressure, heart disease, stroke, diabetes, memory problems, fatigue, sleepiness, and impaired memory.Participants will be compensated for their travel and time throughout the course of the study.Dimethylfumarate is an inhibitor of cytokine-induced E-selectin, VCAM-1, and ICAM-1 expression in human endothelial cells.At the end of the study, participants will undergo a repeat overnight sleep study to monitor for changes in their sleep apnea severity.Dimethyl fumarate - only an anti-psoriatic medication?